We report here that the novel protein kinase C isoform, PKCδ, is required at or prior to the
level of the mitochondria for apoptosis induced by a diverse group of cell toxins. We have
used adenoviral expression of a kinase-dead (KD) mutant of PKCδ to explore the
requirement for PKCδ in the mitochondrial-dependent apoptotic pathway. Expression of
PKCδKD, but not PKCαKD, in salivary epithelial cells resulted in a dose-dependent
inhibition of apoptosis induced by etoposide, UV-irradiation, brefeldin A, and paclitaxel. DNA …