Ceramide in the eukaryotic stress response
YA Hannun, C Luberto - Trends in cell biology, 2000 - cell.com
YA Hannun, C Luberto
Trends in cell biology, 2000•cell.comSeveral extracellular agents and stress stimuli, such as tumour necrosis factor α,
chemotherapeutic agents and heat, cause ceramide accumulation. They do this by
regulating enzymes involved in its metabolism. Ceramide modulates a number of
biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell
senescence.
chemotherapeutic agents and heat, cause ceramide accumulation. They do this by
regulating enzymes involved in its metabolism. Ceramide modulates a number of
biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell
senescence.
Abstract
Several extracellular agents and stress stimuli, such as tumour necrosis factor α, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.
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