[HTML][HTML] Surfactant proteins A and D bind CD14 by different mechanisms
H Sano, H Chiba, D Iwaki, H Sohma, DR Voelker… - Journal of Biological …, 2000 - ASBMB
Surfactant proteins A (SP-A) and D (SP-D) are lung collectins that are constituents of the
innate immune system of the lung. Recent evidence (Sano, H., Sohma, H., Muta, T., Nomura,
S., Voelker, DR, and Kuroki, Y.(1999) J. Immunol. 163, 387–395) demonstrates that SP-A
modulates lipopolysaccharide (LPS)-induced cellular responses by direct interaction with
CD14. In this report we examined the structural elements of the lung collectins involved in
CD14 recognition and the consequences for CD14/LPS interaction. Rat SP-A and SP-D …
innate immune system of the lung. Recent evidence (Sano, H., Sohma, H., Muta, T., Nomura,
S., Voelker, DR, and Kuroki, Y.(1999) J. Immunol. 163, 387–395) demonstrates that SP-A
modulates lipopolysaccharide (LPS)-induced cellular responses by direct interaction with
CD14. In this report we examined the structural elements of the lung collectins involved in
CD14 recognition and the consequences for CD14/LPS interaction. Rat SP-A and SP-D …