[HTML][HTML] Suppression of macrophage responses to bacterial lipopolysaccharide by a non-secretory form of secretory leukocyte protease inhibitor
J Zhu, C Nathan, A Ding - Biochimica et Biophysica Acta (BBA)-Molecular …, 1999 - Elsevier
J Zhu, C Nathan, A Ding
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1999•ElsevierExpression of secretory leukocyte protease inhibitor (SLPI) suppresses the ability of
macrophages to respond to bacterial lipopolysaccharide (LPS). Here, addition of
recombinant or native SLPI to the extracellular medium was non-suppressive, while
transfection with a non-secretory form of SLPI was fully suppressive, an effect overcome by
treatment with interferon-γ. A portion of the SLPI produced by untransfected macrophages
was localized in the cytosol. Thus, SLPI can act intracellularly to block macrophage …
macrophages to respond to bacterial lipopolysaccharide (LPS). Here, addition of
recombinant or native SLPI to the extracellular medium was non-suppressive, while
transfection with a non-secretory form of SLPI was fully suppressive, an effect overcome by
treatment with interferon-γ. A portion of the SLPI produced by untransfected macrophages
was localized in the cytosol. Thus, SLPI can act intracellularly to block macrophage …
Expression of secretory leukocyte protease inhibitor (SLPI) suppresses the ability of macrophages to respond to bacterial lipopolysaccharide (LPS). Here, addition of recombinant or native SLPI to the extracellular medium was non-suppressive, while transfection with a non-secretory form of SLPI was fully suppressive, an effect overcome by treatment with interferon-γ. A portion of the SLPI produced by untransfected macrophages was localized in the cytosol. Thus, SLPI can act intracellularly to block macrophage activation by LPS.
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