Abstract Copolymer-1 (Cop-1) has been shown to inhibit in vivo development of
experimental allergic encephalomyelitis (EAE) in animals and has been reported to have
some therapeutic benefit in relapsing/remitting multiple sclerosis (MS). The mechanism by
which Cop-1 acts in vivo is not known. The present study demonstrates that Cop-1 inhibits
the in vitro response of several antigen-specific murine T cell hybridomas restricted to IA,
and to a lesser extent, IE. The ability of human myelin basic protein (MBP)-specific T cell …