[HTML][HTML] Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells
DE Richard, E Berra, J Pouysségur - Journal of Biological Chemistry, 2000 - ASBMB
Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as
vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions
(hypoxia). VEGF is strongly induced at both the mRNA and protein expression level by a
number of hormones and growth factors in vascular smooth muscle cells (VSMC)
independently of the oxygen environment. However, the role of HIF-1α in this induction has
not been studied. We report here that HIF-1α protein levels are strongly increased by fetal …
vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions
(hypoxia). VEGF is strongly induced at both the mRNA and protein expression level by a
number of hormones and growth factors in vascular smooth muscle cells (VSMC)
independently of the oxygen environment. However, the role of HIF-1α in this induction has
not been studied. We report here that HIF-1α protein levels are strongly increased by fetal …