[HTML][HTML] Chymase as a proangiogenic factor: a possible involvement of chymase-angiotensin-dependent pathway in the hamster sponge angiogenesis model
M Muramatsu, J Katada, I Hayashi, M Majima - Journal of Biological …, 2000 - ASBMB
We investigated the profound involvement of chymase, an alternative angiotensin II-
generating enzyme, in angiogenesis using a hamster sponge implant model. In
vivotransfection of human pro-chymase cDNA or a direct injection of purified chymase into
the sponges implanted resulted in marked increment of hemoglobin contents in the sponge
granuloma tissues, demonstrating that chymase has an ability to elicit angiogenesis and is a
potent angiogenic factor. Daily injection of basic fibroblast growth factor into the sponges …
generating enzyme, in angiogenesis using a hamster sponge implant model. In
vivotransfection of human pro-chymase cDNA or a direct injection of purified chymase into
the sponges implanted resulted in marked increment of hemoglobin contents in the sponge
granuloma tissues, demonstrating that chymase has an ability to elicit angiogenesis and is a
potent angiogenic factor. Daily injection of basic fibroblast growth factor into the sponges …