Structure of the human Nkx2. 1 gene

H Hamdan, H Liu, C Li, C Jones, M Lee… - … et Biophysica Acta (BBA …, 1998 - Elsevier
NKX2. 1 is a member of the NK2 family of homeodomain-containing transcriptional factors
which binds to and activates the promoters of thyroid and pulmonary epithelial genes. We
have cloned and sequenced twelve human lung Nkx2. 1 cDNAs. To elucidate the origin of
Nkx2. 1 transcripts, we also cloned and sequenced a 12 kb human Nkx2. 1 genomic clone.
Alignment of cDNA sequences with the genomic clone showed that contrary to previous
reports, the human Nkx2. 1 gene is organized into three exons and two introns. The newly …