[HTML][HTML] Recruitment of Stat4 to the human interferon-α/β receptor requires activated Stat2

JD Farrar, JD Smith, TL Murphy, KM Murphy - Journal of Biological …, 2000 - ASBMB
Stat4 activation is involved in differentiation of type 1 helper (Th1) T cells. Although Stat4 is
activated by interleukin (IL)-12 in both human and murine T cells, Stat4 is activated by
interferon (IFN)-α only in human, but not murine, CD4+ T cells. This species-specific
difference in cytokine activation of Stat4 underlies critical differences in Th1 development in
response to cytokines and is important to the interpretation of murine models of
immunopathogenesis. Here, we sought to determine the mechanism of Stat4 recruitment …