GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
IL-12 and IL-4 are dominant factors driving the development of Th1 and Th2 cells,
respectively, by their activation of Stat-4 and Stat-6 signaling molecules. Activation of Stat
factors, although specific, is a rapid event; however, differentiation of Th cells takes place
over several days. Thus, it is unlikely that the expression of effector cytokines is mediated
solely by Stat factors. Recently there have been indications that link other molecular factors
to Th subset development. The transcription factor GATA-3 is selectively expressed in Th2 …
respectively, by their activation of Stat-4 and Stat-6 signaling molecules. Activation of Stat
factors, although specific, is a rapid event; however, differentiation of Th cells takes place
over several days. Thus, it is unlikely that the expression of effector cytokines is mediated
solely by Stat factors. Recently there have been indications that link other molecular factors
to Th subset development. The transcription factor GATA-3 is selectively expressed in Th2 …