IκB-β regulates the persistent response in a biphasic activation of NF-κB
JE Thompson, RJ Phillips, H Erdjument-Bromage… - Cell, 1995 - cell.com
JE Thompson, RJ Phillips, H Erdjument-Bromage, P Tempst, S Ghosh
Cell, 1995•cell.comWe have cloned the cDNA encoding IKB-I~, one of the two major IKB isoforms in mammalian
cells. The recombinant IKB-p protein interacts with equal affinity to p65 and c-Rel and does
not exhibit a preference between these Rel proteins, instead the primary difference between
IKB-a and IKB-I~ iS in their response to different inducers of NF-KB activity. One class of
inducers causes rapid but transient activation of NF-KB by primarily affecting IKB-e
complexes, whereas another class of inducers causes persistent activation of NF-KB by …
cells. The recombinant IKB-p protein interacts with equal affinity to p65 and c-Rel and does
not exhibit a preference between these Rel proteins, instead the primary difference between
IKB-a and IKB-I~ iS in their response to different inducers of NF-KB activity. One class of
inducers causes rapid but transient activation of NF-KB by primarily affecting IKB-e
complexes, whereas another class of inducers causes persistent activation of NF-KB by …
Summary
We have cloned the cDNA encoding IKB-I~, one of the two major IKB isoforms in mammalian cells. The recombinant IKB-p protein interacts with equal affinity to p65 and c-Rel and does not exhibit a preference between these Rel proteins, instead the primary difference between IKB-a and IKB-I~ iS in their response to different inducers of NF-KB activity. One class of inducers causes rapid but transient activation of NF-KB by primarily affecting IKB-e complexes, whereas another class of inducers causes persistent activation of NF-KB by affecting both IKB-a and IKB-J~ complexes. Therefore, the overall activation of NF-KB consists of two overlapping phases, a transient phase mediated through IKB-(L and a persistent phase mediated through IKB-I~.
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