[HTML][HTML] NF-κB activation is required for human endothelial survival during exposure to tumor necrosis factor-α but not to interleukin-1β or lipopolysaccharide
K Zen, A Karsan, A Stempien-Otero, E Yee… - Journal of Biological …, 1999 - ASBMB
In the presence of a protein synthesis inhibitor, cycloheximide, tumor necrosis factor-α (TNF-
α), interleukin 1-β (IL-1β), or lipopolysaccharide (LPS) induces human umbilical vein
endothelial cells (HUVECs) to undergo apoptosis, suggesting that constitutive or inducible
cytoprotective pathways are required for cell survival. We studied the correlation between
nuclear factor-κB (NF-κB) activation and cell death induced by TNF-α, IL-1β, or LPS.
Adenovirus-mediated overexpression of a dominant-negative IκBα (inhibitor of κB) mutant …
α), interleukin 1-β (IL-1β), or lipopolysaccharide (LPS) induces human umbilical vein
endothelial cells (HUVECs) to undergo apoptosis, suggesting that constitutive or inducible
cytoprotective pathways are required for cell survival. We studied the correlation between
nuclear factor-κB (NF-κB) activation and cell death induced by TNF-α, IL-1β, or LPS.
Adenovirus-mediated overexpression of a dominant-negative IκBα (inhibitor of κB) mutant …