Calculation of lytic units for the expression of cell-mediated cytotoxicity
J Bryant, R Day, TL Whiteside… - Journal of immunological …, 1992 - Elsevier
Over the past 10 years, the lytic unit has become the most common means by which activity
is expressed in cell-mediated cytotoxicity assays. The strengths and weaknesses of the lytic
unit as a summary of cytotoxicity are discussed, and computational methods reviewed. The
fundamental “assumption of proportional effect” which is implicit in the interpretation of lytic
units is described and empirically tested. Based on extensive data from the assay of human
natural killer (NK) activity against K562 targets, simplified computational methods are …
is expressed in cell-mediated cytotoxicity assays. The strengths and weaknesses of the lytic
unit as a summary of cytotoxicity are discussed, and computational methods reviewed. The
fundamental “assumption of proportional effect” which is implicit in the interpretation of lytic
units is described and empirically tested. Based on extensive data from the assay of human
natural killer (NK) activity against K562 targets, simplified computational methods are …