Activation of epithelial sodium channels by prostasin in Xenopus oocytes
M Adachi, K Kitamura, T Miyoshi… - Journal of the …, 2001 - journals.lww.com
Prostasin, a novel serine protease, was purified from seminal fluid, and its cDNA sequence
was determined. Expression of prostasin was detected in human tissues, including prostate,
kidney, and lung, as well as bodily fluids, including seminal fluid and urine. However, its
physiologic role in the human body is not known. Recently, a novel regulatory mechanism
by which serine proteases activate epithelial sodium channel in the Xenopus oocyte was
identified. Therefore, it was hypothesized that prostasin could activate sodium currents, and …
was determined. Expression of prostasin was detected in human tissues, including prostate,
kidney, and lung, as well as bodily fluids, including seminal fluid and urine. However, its
physiologic role in the human body is not known. Recently, a novel regulatory mechanism
by which serine proteases activate epithelial sodium channel in the Xenopus oocyte was
identified. Therefore, it was hypothesized that prostasin could activate sodium currents, and …