[HTML][HTML] Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent …
K Suzuma, K Naruse, I Suzuma, N Takahara… - Journal of Biological …, 2000 - ASBMB
Fibroblastic proliferation accompanies many angiogenesis-related retinal and systemic
diseases. Since connective tissue growth factor (CTGF) is a potent mitogen for fibrosis,
extracellular matrix production, and angiogenesis, we have studied the effects and
mechanism by which vascular endothelial growth factor (VEGF) regulates CTGF gene
expression in retinal capillary cells. In our study, VEGF increased CTGF mRNA levels in a
time-and concentration-dependent manner in bovine retinal endothelial cells and pericytes …
diseases. Since connective tissue growth factor (CTGF) is a potent mitogen for fibrosis,
extracellular matrix production, and angiogenesis, we have studied the effects and
mechanism by which vascular endothelial growth factor (VEGF) regulates CTGF gene
expression in retinal capillary cells. In our study, VEGF increased CTGF mRNA levels in a
time-and concentration-dependent manner in bovine retinal endothelial cells and pericytes …