Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2-and …
V Vielhauer, HJ Anders, M Mack, J Cihak… - Journal of the …, 2001 - journals.lww.com
The infiltration of leukocytes plays a major role in mediating tubulointerstitial inflammation
and fibrosis in chronic renal disease. CC chemokines participate in leukocyte migration and
infiltration into inflamed renal tissue. Because CC chemokine-directed leukocyte migration is
mediated by target cell expression of a group of CC chemokine receptors, this study
examined the expression of CC chemokines and their receptors during initiation of
tubulointerstitial fibrosis after unilateral ureteral obstruction in C57BL/6 mice. Obstructed …
and fibrosis in chronic renal disease. CC chemokines participate in leukocyte migration and
infiltration into inflamed renal tissue. Because CC chemokine-directed leukocyte migration is
mediated by target cell expression of a group of CC chemokine receptors, this study
examined the expression of CC chemokines and their receptors during initiation of
tubulointerstitial fibrosis after unilateral ureteral obstruction in C57BL/6 mice. Obstructed …