CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model
R Horuk, S Shurey, HP Ng, K May, JG Bauman… - Immunology …, 2001 - Elsevier
The classic signs of acute cellular rejection during organ transplantation include the
infiltration of mononuclear cells into the interstitium. This recruitment of leukocytes into the
transplanted tissue is promoted by chemokines like RANTES. Since RANTES is a potent
agonist for the CC chemokine receptor CCR1, we examined whether the CCR1 antagonist
BX 471 was efficacious in a rabbit kidney transplant rejection model. BX 471 was able to
compete with high affinity with the CCR1 ligands MIP-1α and RANTES for binding to HEK …
infiltration of mononuclear cells into the interstitium. This recruitment of leukocytes into the
transplanted tissue is promoted by chemokines like RANTES. Since RANTES is a potent
agonist for the CC chemokine receptor CCR1, we examined whether the CCR1 antagonist
BX 471 was efficacious in a rabbit kidney transplant rejection model. BX 471 was able to
compete with high affinity with the CCR1 ligands MIP-1α and RANTES for binding to HEK …