Heparin cofactor II inhibits thrombus formation in a rat thrombosis model
K Yamanaga, T Yuuki, M Tsukada, H Koshiba… - Thrombosis research, 2000 - Elsevier
Heparin cofactor II is postulated to be an extravascular thrombin inhibitor that is
physiologically stimulated by dermatan sulfate. However, the role of heparin cofactor II has
not yet been clearly demonstrated in vivo. In this study, we estimated the antithrombotic
effect of heparin cofactor II administered exogenously in a rat model of thrombosis.
Thrombus was induced in the rat femoral artery by endothelial damage due to the
photochemical reaction between systemically injected rose bengal and transillumination …
physiologically stimulated by dermatan sulfate. However, the role of heparin cofactor II has
not yet been clearly demonstrated in vivo. In this study, we estimated the antithrombotic
effect of heparin cofactor II administered exogenously in a rat model of thrombosis.
Thrombus was induced in the rat femoral artery by endothelial damage due to the
photochemical reaction between systemically injected rose bengal and transillumination …
