[HTML][HTML] Chk, a Csk family tyrosine protein kinase, exhibits Csk-like activity in fibroblasts, but not in an antigen-specific T-cell line
D Davidson, LML Chow, A Veillette - Journal of Biological Chemistry, 1997 - ASBMB
The Csk family of tyrosine protein kinases comprises two members named Csk and Chk.
These enzymes phosphorylate the carboxyl-terminal tyrosine of Src-related kinases in vitro,
thereby repressing their activity. Csk has been found to be necessary for normal embryonic
development, and to be a potent negative regulator of antigen receptor signaling in T-
lymphocytes. As the functions of Chk in mammalian cells are not known, we examined its
ability to carry out Csk-like functions in vivo. Like p50 csk, Chk reduced the elevated …
These enzymes phosphorylate the carboxyl-terminal tyrosine of Src-related kinases in vitro,
thereby repressing their activity. Csk has been found to be necessary for normal embryonic
development, and to be a potent negative regulator of antigen receptor signaling in T-
lymphocytes. As the functions of Chk in mammalian cells are not known, we examined its
ability to carry out Csk-like functions in vivo. Like p50 csk, Chk reduced the elevated …