[HTML][HTML] Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells
D Davidson, JF Cloutier, A Gregorieff… - Journal of Biological …, 1997 - ASBMB
p50 csk is a cytosolic tyrosine protein kinase expressed in all cell types. Accumulating data
show that it inhibits multiple cellular processes, as a consequence of its ability to repress the
enzymatic activity of Src family tyrosine protein kinases. We previously demonstrated that,
via its Src homology 3 (SH3) domain, Csk is tightly bound to PEP, a protein-tyrosine
phosphatase (PTP) exclusively expressed in hemopoietic cells. In this report, we have tested
the possibility that Csk also interacts with PTP-PEST, a ubiquitous PTP sharing structural …
show that it inhibits multiple cellular processes, as a consequence of its ability to repress the
enzymatic activity of Src family tyrosine protein kinases. We previously demonstrated that,
via its Src homology 3 (SH3) domain, Csk is tightly bound to PEP, a protein-tyrosine
phosphatase (PTP) exclusively expressed in hemopoietic cells. In this report, we have tested
the possibility that Csk also interacts with PTP-PEST, a ubiquitous PTP sharing structural …