Function and regulation of collecting duct intercalated cells
VL Schuster - Annual review of physiology, 1993 - annualreviews.org
Annual review of physiology, 1993•annualreviews.org
Renal intercalated cells (IC) are interspersed among the segment-specific majority
(principal) cells of the distal convoluted tubule, connecting tubule, and collecting duct (71,
144). Ultrastructurally, ICs are distinguished by their dark cytoplasm, high mitochondrial
density, cytoplasmic tubulovesicular structures, and apical microprojections (87). There are
two major collecting duct IC SUbtypes, and they mediate H+ and HC03 secretion, and CI
and K+ reabsorption (116-119, 123). This review focuses on immunocytochemistry and …
(principal) cells of the distal convoluted tubule, connecting tubule, and collecting duct (71,
144). Ultrastructurally, ICs are distinguished by their dark cytoplasm, high mitochondrial
density, cytoplasmic tubulovesicular structures, and apical microprojections (87). There are
two major collecting duct IC SUbtypes, and they mediate H+ and HC03 secretion, and CI
and K+ reabsorption (116-119, 123). This review focuses on immunocytochemistry and …
Renal intercalated cells (IC) are interspersed among the segment-specific majority (principal) cells of the distal convoluted tubule, connecting tubule, and collecting duct (71, 144). Ultrastructurally, ICs are distinguished by their dark cytoplasm, high mitochondrial density, cytoplasmic tubulovesicular structures, and apical microprojections (87). There are two major collecting duct IC SUbtypes, and they mediate H+ and HC03 secretion, and CI and K+ reabsorption (116-119, 123).
This review focuses on immunocytochemistry and perfused tubule data from ICs of rabbit and rat cortical collecting duct (CCD) and outer medullary collecting duct (OMCD), with emphasis on six areas:(a) functional and immunocytochemical characteristics of IC SUbtypes;(b) axial distribution along the collecting duct;(c) regulation by l3-adrenergic agonists;(d) regulation by systemic acid-base perturbations;(e) regulation by aldosterone; and if> plasticity of IC transporter polarity and expression.
Annual Reviews