Eight subjects inoculated orally with live attenuated poliovirus were investigated to study the
effects of live virus infection on human T-cell responses. Proliferation to poliovirus and
unrelated recall antigens were measured serially over a 3-week period. Five of eight
subjects inoculated demonstrated a clear anamnestic response to poliovirus, but three did
not. Only the five subjects demonstrating an anamnestic response to poliovirus were found
to have augmented secondary immune responses to two unrelated recall antigens (tetanus …