Cyclin-dependent kinases: engines, clocks, and microprocessors
DO Morgan - Annual review of cell and developmental biology, 1997 - annualreviews.org
Annual review of cell and developmental biology, 1997•annualreviews.org
▪ Abstract Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of
the eukaryotic cell division cycle and have also been implicated in the control of gene
transcription and other processes. Cdk activity is governed by a complex network of
regulatory subunits and phosphorylation events whose precise effects on Cdk conformation
have been revealed by recent crystallographic studies. In the cell, these regulatory
mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell …
the eukaryotic cell division cycle and have also been implicated in the control of gene
transcription and other processes. Cdk activity is governed by a complex network of
regulatory subunits and phosphorylation events whose precise effects on Cdk conformation
have been revealed by recent crystallographic studies. In the cell, these regulatory
mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell …
▪ Abstract
Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.
Annual Reviews