[HTML][HTML] Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts

VA Fadok, A De Cathelineau, DL Daleke… - Journal of Biological …, 2001 - ASBMB
Removal of apoptotic cells during tissue remodeling or resolution of inflammation is critical
to the restoration of normal tissue structure and function. During apoptosis, early surface
changes occur, which trigger recognition and removal by macrophages and other
phagocytes. Loss of phospholipid asymmetry results in exposure of phosphatidylserine (PS),
one of the surface markers recognized by macrophages. However, a number of receptors
have been reported to mediate macrophage recognition of apoptotic cells, not all of which …