Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice
A Gessner, H Blum, M Röllinghoff - Immunobiology, 1993 - Elsevier
IL-9 is a pleiotropic lymphokine, one of its activities being the growth stimulation of certain
CD4+ T lymphocytes. In murine cutaneous leishmaniasis, depending on the genetic
background of the host mouse strain, vigorous proliferation of either mainly Th1 in resistant
C57BL/6 mice or Th2-type CD4+ T cells in susceptible BALB/c mice occurs after infection
with Leishmania major (L. major). Since little is known about the involvement of IL-9, the
possible role of this cytokine with regard to its immunregulatory function was evaluated by …
CD4+ T lymphocytes. In murine cutaneous leishmaniasis, depending on the genetic
background of the host mouse strain, vigorous proliferation of either mainly Th1 in resistant
C57BL/6 mice or Th2-type CD4+ T cells in susceptible BALB/c mice occurs after infection
with Leishmania major (L. major). Since little is known about the involvement of IL-9, the
possible role of this cytokine with regard to its immunregulatory function was evaluated by …