Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes
S Houldsworth, PW Andrew, TJ Mitchell - Infection and immunity, 1994 - Am Soc Microbiol
S Houldsworth, PW Andrew, TJ Mitchell
Infection and immunity, 1994•Am Soc MicrobiolHuman peripheral blood monocytes and a human monocyte cell line were exposed to the
toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of
tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The
viability of cells was not affected by the concentrations of pneumolysin used in the
experiments.
toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of
tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The
viability of cells was not affected by the concentrations of pneumolysin used in the
experiments.
Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.
American Society for Microbiology