[HTML][HTML] Specific increase in p85α expression in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated phosphatidylinositol …
F Giorgino, MT Pedrini, L Matera, RJ Smith - Journal of Biological Chemistry, 1997 - ASBMB
The stimulation of phosphatidylinositol (PI) 3-kinase by insulin-like growth factor I (IGF-I) in
L6 cultured skeletal muscle cells is inhibited by the glucocorticoid dexamethasone. The
objective of this study was to investigate the mechanism of dexamethasone action by
determining its effects on the expression of the p85α and p85β regulatory subunit isoforms of
PI 3-kinase, their coupling with the p110 catalytic subunit, and their association with insulin
receptor substrate 1 (IRS-1) in response to IGF-I stimulation. Dexamethasone induced a …
L6 cultured skeletal muscle cells is inhibited by the glucocorticoid dexamethasone. The
objective of this study was to investigate the mechanism of dexamethasone action by
determining its effects on the expression of the p85α and p85β regulatory subunit isoforms of
PI 3-kinase, their coupling with the p110 catalytic subunit, and their association with insulin
receptor substrate 1 (IRS-1) in response to IGF-I stimulation. Dexamethasone induced a …