[HTML][HTML] Peroxisome proliferator-activated receptor α controls the hepatic CYP4A induction adaptive response to starvation and diabetes
DL Kroetz, P Yook, P Costet, P Bianchi… - Journal of Biological …, 1998 - ASBMB
The hepatic CYP4A enzymes are important fatty acid and prostaglandin ω-hydroxylases that
are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators.
Induction of the CYP4A enzymes by peroxisome proliferators is mediated through the
nuclear peroxisome proliferator-activated receptor α (PPARα). Fatty acids have recently
been identified as endogenous ligands of PPARα, and this receptor has been implicated in
the regulation of lipid homeostasis. In the present report we characterized the induction of …
are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators.
Induction of the CYP4A enzymes by peroxisome proliferators is mediated through the
nuclear peroxisome proliferator-activated receptor α (PPARα). Fatty acids have recently
been identified as endogenous ligands of PPARα, and this receptor has been implicated in
the regulation of lipid homeostasis. In the present report we characterized the induction of …