Interleukin-18: a novel cytokine that augments both innate and acquired immunity
H Okamura, H Tsutsui, SI Kashiwamura… - Advances in …, 1998 - Elsevier
Publisher Summary Interleukin-18 (IL-18) is a multifunctional cytokine, the roles of which
extend over both acquired and innate immunity, and its major role has been thought to be
the strong ability to induce IFN-γ production from T or NK cells. This chapter describes the IL-
18/IL-l8R system and its pathophysiological roles in immune response. Although IL-18-
producing cells were thought to be activated macrophages at first, recent investigations
reveal that various types of cells, including keratinocytes, osteoclasts, and adrenal cortex …
extend over both acquired and innate immunity, and its major role has been thought to be
the strong ability to induce IFN-γ production from T or NK cells. This chapter describes the IL-
18/IL-l8R system and its pathophysiological roles in immune response. Although IL-18-
producing cells were thought to be activated macrophages at first, recent investigations
reveal that various types of cells, including keratinocytes, osteoclasts, and adrenal cortex …