[HTML][HTML] Identification and initial characterization of four novel members of the interleukin-1 family
S Kumar, PC McDonnell, R Lehr, L Tierney… - Journal of Biological …, 2000 - ASBMB
Interleukin-1 (IL-1), fibroblast growth factors (FGFs), and their homologues are secreted
factors that share a common β-barrel structure and act on target cells by binding to cell
surface receptors with immunoglobulin-like folds in their extracellular domain. While
numerous members of the FGF family have been discovered, the IL-1 family has remained
small and outnumbered by IL-1 receptor homologues. From expressed sequence tag data
base searches, we have now identified four additional IL-1 homologues, IL-1H1, IL-1H2, IL …
factors that share a common β-barrel structure and act on target cells by binding to cell
surface receptors with immunoglobulin-like folds in their extracellular domain. While
numerous members of the FGF family have been discovered, the IL-1 family has remained
small and outnumbered by IL-1 receptor homologues. From expressed sequence tag data
base searches, we have now identified four additional IL-1 homologues, IL-1H1, IL-1H2, IL …