The third function of the thymus
B Seddon, D Mason - Immunology today, 2000 - cell.com
B Seddon, D Mason
Immunology today, 2000•cell.comNonresponsiveness of mammalian T cells to self-antigens is not totally accounted for in
terms of clonal deletion, T-cell anergy and T-cell ignorance: studies have shown that the T-
cell repertoire of healthy individuals contains cells with the potential to cause autoimmune
disease. This article describes a T-cell-mediated mechanism that prevents the realization of
this potential and indicates how its failure can lead to the development of autoimmunity.
terms of clonal deletion, T-cell anergy and T-cell ignorance: studies have shown that the T-
cell repertoire of healthy individuals contains cells with the potential to cause autoimmune
disease. This article describes a T-cell-mediated mechanism that prevents the realization of
this potential and indicates how its failure can lead to the development of autoimmunity.
Abstract
Nonresponsiveness of mammalian T cells to self-antigens is not totally accounted for in terms of clonal deletion, T-cell anergy and T-cell ignorance: studies have shown that the T-cell repertoire of healthy individuals contains cells with the potential to cause autoimmune disease. This article describes a T-cell-mediated mechanism that prevents the realization of this potential and indicates how its failure can lead to the development of autoimmunity.
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