[HTML][HTML] Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74
MM Rosenkilde, TN Kledal… - Journal of Biological …, 1999 - ASBMB
A number of CXC chemokines competed with similar, nanomolar affinity against 125 I-
interleukin-8 (IL-8) binding to ORF-74, a constitutively active seven-transmembrane receptor
encoded by human herpesvirus 8. However, in competition against 125 I-labeled growth-
related oncogene (GRO)-α, the ORF-74 receptor was highly selective for GRO peptides, with
IL-8 being 10,000-fold less potent. The constitutive stimulating activity of ORF-74 on
phosphatidylinositol turnover was not influenced by, for example, IL-8 binding. In contrast …
interleukin-8 (IL-8) binding to ORF-74, a constitutively active seven-transmembrane receptor
encoded by human herpesvirus 8. However, in competition against 125 I-labeled growth-
related oncogene (GRO)-α, the ORF-74 receptor was highly selective for GRO peptides, with
IL-8 being 10,000-fold less potent. The constitutive stimulating activity of ORF-74 on
phosphatidylinositol turnover was not influenced by, for example, IL-8 binding. In contrast …