[HTML][HTML] A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
TR6 (decoy receptor 3 (DcR3)) is a new member of the tumor necrosis factor receptor
(TNFR) family. TR6 mRNA is expressed in lung tissues and colon adenocarcinoma, SW480.
In addition, the expression of TR6 mRNA was shown in the endothelial cell line and induced
by phorbol 12-myristate 13-acetate/ionomycin in Jurkat T leukemia cells. The open reading
frame of TR6 encodes 300 amino acids with a 29-residue signal sequence but no
transmembrane region. Using histidine-tagged recombinant TR6, we screened soluble …
(TNFR) family. TR6 mRNA is expressed in lung tissues and colon adenocarcinoma, SW480.
In addition, the expression of TR6 mRNA was shown in the endothelial cell line and induced
by phorbol 12-myristate 13-acetate/ionomycin in Jurkat T leukemia cells. The open reading
frame of TR6 encodes 300 amino acids with a 29-residue signal sequence but no
transmembrane region. Using histidine-tagged recombinant TR6, we screened soluble …