Oxidation of heparin-treated low density lipoprotein by peroxidases

JE Upritchard, WHF Sutherland - Atherosclerosis, 1999 - Elsevier
Low density lipoproteins (LDL) can bind to glycosaminoglycans and proteoglycans rich in
heparin and chondroitin sulphate in the arterial intima and may become a target for
atherogenic modification by myeloperoxidase activity. We have examined the susceptibility
of resolubilized LDL, that has been precipitated from serum with heparin (HepLDL), to
peroxidase–H2O2-catalysed oxidation and the effects of antioxidants and components of
human serum on the oxidation. HepLDL was oxidised rapidly by horse radish peroxidase …