[HTML][HTML] The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
MM Song, K Shuai - Journal of Biological Chemistry, 1998 - ASBMB
The suppressor of cytokine signaling (SOCS) proteins are a family of cytokine-inducible
negative regulators of cytokine signaling. Interferon (IFN)-γ treatment induces the expression
of SOCS1, SOCS2, and SOCS3 mRNAs. To examine the effect of SOCS proteins on IFN-
mediated Janus-activated kinase/signal transducers and activators of transcription (STAT)
signaling, HeLa-and MCF-7-derived stable cell lines expressing SOCS1, SOCS2, and
SOCS3 proteins were established. SOCS1 and SOCS3 but not SOCS2 inhibited the tyrosine …
negative regulators of cytokine signaling. Interferon (IFN)-γ treatment induces the expression
of SOCS1, SOCS2, and SOCS3 mRNAs. To examine the effect of SOCS proteins on IFN-
mediated Janus-activated kinase/signal transducers and activators of transcription (STAT)
signaling, HeLa-and MCF-7-derived stable cell lines expressing SOCS1, SOCS2, and
SOCS3 proteins were established. SOCS1 and SOCS3 but not SOCS2 inhibited the tyrosine …