[HTML][HTML] The role of SOCS-3 in leptin signaling and leptin resistance
C Bjørbæk, K El-Haschimi, JD Frantz, JS Flier - Journal of Biological …, 1999 - ASBMB
We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the
hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin
signaling. However, little is known about the regulation of SOCS-3 expression by leptin and
the mechanism by which SOCS-3 inhibits leptin action. We here show that in CHO cells
stably expressing the long form of the leptin receptor (CHO-OBRl), leptin induces transient
expression of endogenous SOCS-3 mRNA but not of CIS, SOCS-1, or SOCS-2 mRNA …
hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin
signaling. However, little is known about the regulation of SOCS-3 expression by leptin and
the mechanism by which SOCS-3 inhibits leptin action. We here show that in CHO cells
stably expressing the long form of the leptin receptor (CHO-OBRl), leptin induces transient
expression of endogenous SOCS-3 mRNA but not of CIS, SOCS-1, or SOCS-2 mRNA …