CD3-and CD28-dependent induction of PDE7 required for T cell activation
L Li, C Yee, JA Beavo - Science, 1999 - science.org
L Li, C Yee, JA Beavo
Science, 1999•science.orgCostimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction
of adenosine 3′, 5′-monophosphate (cAMP)–specific phosphodiesterase-7 (PDE7) was
found to be a consequence of such costimulation. Increased PDE7 in T cells correlated with
decreased cAMP, increased interleukin-2 expression, and increased proliferation.
Selectively reducing PDE7 expression with a PDE7 antisense oligonucleotide inhibited T
cell proliferation; inhibition was reversed by blocking the cAMP signaling pathways that …
of adenosine 3′, 5′-monophosphate (cAMP)–specific phosphodiesterase-7 (PDE7) was
found to be a consequence of such costimulation. Increased PDE7 in T cells correlated with
decreased cAMP, increased interleukin-2 expression, and increased proliferation.
Selectively reducing PDE7 expression with a PDE7 antisense oligonucleotide inhibited T
cell proliferation; inhibition was reversed by blocking the cAMP signaling pathways that …
Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3′,5′-monophosphate (cAMP)–specific phosphodiesterase-7 (PDE7) was found to be a consequence of such costimulation. Increased PDE7 in T cells correlated with decreased cAMP, increased interleukin-2 expression, and increased proliferation. Selectively reducing PDE7 expression with a PDE7 antisense oligonucleotide inhibited T cell proliferation; inhibition was reversed by blocking the cAMP signaling pathways that operate through cAMP-dependent protein kinase (PKA). Thus, PDE7 induction and consequent suppression of PKA activity is required for T cell activation, and inhibition of PDE7 could be an approach to treating T cell–dependent disorders.
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