[HTML][HTML] Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor whose expression is
dramatically induced by hypoxia due in large part to an increase in the stability of its mRNA.
Here we show that HuR binds with high affinity and specificity to the element that regulates
VEGF mRNA stability by hypoxia. Inhibition of HuR expression abrogates the hypoxia-
mediated increase in VEGF mRNA stability. Overexpression of HuR increases the stability of
VEGF mRNA. However, this only occurs efficiently in hypoxic cells. We further show that the …
dramatically induced by hypoxia due in large part to an increase in the stability of its mRNA.
Here we show that HuR binds with high affinity and specificity to the element that regulates
VEGF mRNA stability by hypoxia. Inhibition of HuR expression abrogates the hypoxia-
mediated increase in VEGF mRNA stability. Overexpression of HuR increases the stability of
VEGF mRNA. However, this only occurs efficiently in hypoxic cells. We further show that the …