[HTML][HTML] Self-promotion? Intimate connections between APC and prostaglandin H synthase-2
SM Prescott, RL White - Cell, 1996 - cell.com
SM Prescott, RL White
Cell, 1996•cell.comColon cancer is a paradigm for the multistep genetic basis of cancer. Several initiating
mutations have been identified by studying families with inherited predisposition to colon
cancer and its long-lived intermediate, the adenomatous polyp. For example, in Familial
Adenomatous Polyposis the affected individuals develop hundreds of polyps, some of which
progress to cancer. The FAP gene was mapped to chromosome 5q21 and mutations in the
APC gene were identified as the cause (reviewed by
mutations have been identified by studying families with inherited predisposition to colon
cancer and its long-lived intermediate, the adenomatous polyp. For example, in Familial
Adenomatous Polyposis the affected individuals develop hundreds of polyps, some of which
progress to cancer. The FAP gene was mapped to chromosome 5q21 and mutations in the
APC gene were identified as the cause (reviewed by
Colon cancer is a paradigm for the multistep genetic basis of cancer. Several initiating mutations have been identified by studying families with inherited predisposition to colon cancer and its long-lived intermediate, the adenomatous polyp. For example, in Familial Adenomatous Polyposis the affected individuals develop hundreds of polyps, some of which progress to cancer. The FAP gene was mapped to chromosome 5q21 and mutations in the APC gene were identified as the cause (reviewed by
cell.com