[HTML][HTML] Inhibition of insulin-induced GLUT4 translocation by Munc18c through interaction with syntaxin4 in 3T3-L1 adipocytes

Y Tamori, M Kawanishi, T Niki, H Shinoda… - Journal of Biological …, 1998 - ASBMB
Insulin induces the translocation of vesicles containing the glucose transporter GLUT4 from
an intracellular compartment to the plasma membrane in adipocytes. SNARE proteins have
been implicated in the docking and fusion of these vesicles with the cell membrane. The role
of Munc18c, previously identified as an n-Sec1/Munc18 homolog in 3T3-L1 adipocytes, in
insulin-regulated GLUT4 trafficking has now been investigated in 3T3-L1 adipocytes. In
these cells, Munc18c was predominantly associated with syntaxin4, although it bound both …