Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells
JG VAN DEN BERG, J Aten, MA Chand… - Journal of the …, 2000 - journals.lww.com
In minimal change nephrosis (MCN), proteinuria is associated with structural changes of the
glomerular visceral epithelial cells (GVEC). The occurrence of MCN has been associated
with T-helper2 lymphocyte-dependent conditions. To examine a direct role for type 2
cytokines in GVEC injury, the expression of interleukin (IL)-4/IL-13 receptors by GVEC and
direct effects of IL-4 and IL-13 on GVEC were studied. Reverse transcription-PCR showed
that isolated human and rat glomeruli and cultured human and rat GVEC expressed mRNA …
glomerular visceral epithelial cells (GVEC). The occurrence of MCN has been associated
with T-helper2 lymphocyte-dependent conditions. To examine a direct role for type 2
cytokines in GVEC injury, the expression of interleukin (IL)-4/IL-13 receptors by GVEC and
direct effects of IL-4 and IL-13 on GVEC were studied. Reverse transcription-PCR showed
that isolated human and rat glomeruli and cultured human and rat GVEC expressed mRNA …