Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin
W Vale, J Spiess, C Rivier, J Rivier - Science, 1981 - science.org
W Vale, J Spiess, C Rivier, J Rivier
Science, 1981•science.orgA peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-
like and β-endorphin-like immunoactivities by cultured anterior pituitary cells has been
purified from ovine hypothalamic extracts. The primary structure of this 41-residue
corticotropin-and β-endorphin-releasing factor has been determined to be: H-Ser-Gln-Glu-
Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-
Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2. The synthetic …
like and β-endorphin-like immunoactivities by cultured anterior pituitary cells has been
purified from ovine hypothalamic extracts. The primary structure of this 41-residue
corticotropin-and β-endorphin-releasing factor has been determined to be: H-Ser-Gln-Glu-
Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-
Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2. The synthetic …
A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphin-like immunoactivities by cultured anterior pituitary cells has been purified from ovine hypothalamic extracts. The primary structure of this 41-residue corticotropin- and β-endorphin-releasing factor has been determined to be: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2. The synthetic peptide is active in vitro and in vivo.
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