Control of vascular smooth muscle cell growth and its implication in atherosclerosis and restenosis
V Andres - International journal of molecular medicine, 1998 - spandidos-publications.com
International journal of molecular medicine, 1998•spandidos-publications.com
Abnormal proliferation of vascular smooth muscle cells (SMCs) is thought to contribute to
neointimal thickening during spontaneous atherosclerosis and vessel renarrowing
(restenosis) after angioplasty. This review will focus on the mechanisms underlying cell-
cycle control in SMCs and its implication in atherosclerosis and restenosis. Therapeutic
approaches that targeted specific cell-cycle control genes or growth regulatory molecules
which effectively inhibited neointimal lesion formation will also be discussed.
neointimal thickening during spontaneous atherosclerosis and vessel renarrowing
(restenosis) after angioplasty. This review will focus on the mechanisms underlying cell-
cycle control in SMCs and its implication in atherosclerosis and restenosis. Therapeutic
approaches that targeted specific cell-cycle control genes or growth regulatory molecules
which effectively inhibited neointimal lesion formation will also be discussed.
Abstract
Abnormal proliferation of vascular smooth muscle cells (SMCs) is thought to contribute to neointimal thickening during spontaneous atherosclerosis and vessel renarrowing (restenosis) after angioplasty. This review will focus on the mechanisms underlying cell-cycle control in SMCs and its implication in atherosclerosis and restenosis. Therapeutic approaches that targeted specific cell-cycle control genes or growth regulatory molecules which effectively inhibited neointimal lesion formation will also be discussed.
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