[HTML][HTML] gp130 plays a critical role in pressure overload-induced cardiac hypertrophy
H Uozumi, Y Hiroi, Y Zou, E Takimoto, H Toko… - Journal of Biological …, 2001 - ASBMB
gp130, a common receptor for the interleukin 6 family, plays pivotal roles in growth and
survival of cardiac myocytes. In the present study, we examined the role of gp130 in
pressure overload-induced cardiac hypertrophy using transgenic (TG) mice, which express
a dominant negative mutant of gp130 in the heart under the control of α myosin heavy chain
promoter. TG mice were apparently healthy and fertile. There were no differences in body
weight and heart weight between TG mice and littermate wild type (WT) mice. Pressure …
survival of cardiac myocytes. In the present study, we examined the role of gp130 in
pressure overload-induced cardiac hypertrophy using transgenic (TG) mice, which express
a dominant negative mutant of gp130 in the heart under the control of α myosin heavy chain
promoter. TG mice were apparently healthy and fertile. There were no differences in body
weight and heart weight between TG mice and littermate wild type (WT) mice. Pressure …