Regulation of human lung fibroblast alpha 1 (I) procollagen gene expression by tumor necrosis factor alpha, interleukin-1 beta, and prostaglandin E2
A Diaz, E Munoz, R Johnston, JH Korn… - Journal of Biological …, 1993 - ASBMB
We investigated the participation of prostaglandin (PG) E2 in the regulation of the alpha 1 (I)
procollagen gene expression by tumor necrosis factor alpha (TNF alpha), and interleukin-1
beta (IL-1 beta) in normal adult human lung fibroblasts. TNF alpha (100 units/ml) and IL-1
beta (100 units/ml) stimulated the production of PGE2 and caused a dose-dependent
inhibition of up to 54 and 66%, respectively, of the production of type I procollagen.
Preincubation of cultures with indomethacin partially reversed the inhibition of procollagen …
procollagen gene expression by tumor necrosis factor alpha (TNF alpha), and interleukin-1
beta (IL-1 beta) in normal adult human lung fibroblasts. TNF alpha (100 units/ml) and IL-1
beta (100 units/ml) stimulated the production of PGE2 and caused a dose-dependent
inhibition of up to 54 and 66%, respectively, of the production of type I procollagen.
Preincubation of cultures with indomethacin partially reversed the inhibition of procollagen …