[HTML][HTML] Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver-and kidney …
RS Streeper, CA Svitek, JK Goldman… - Journal of Biological …, 2000 - ASBMB
In liver and kidney, the terminal step in gluconeogenesis is catalyzed by glucose-6-
phosphatase. To examine the effect of the cAMP signal transduction pathway on
transcription of the gene encoding the catalytic subunit of glucose-6-phosphatase (G6Pase),
G6Pase-chloramphenicol acetyltransferase (CAT) fusion genes were transiently transfected
into either the liver-derived HepG2 or kidney-derived LLC-PK cell line. Co-transfection of an
expression vector encoding the catalytic subunit of cAMP-dependent protein kinase (PKA) …
phosphatase. To examine the effect of the cAMP signal transduction pathway on
transcription of the gene encoding the catalytic subunit of glucose-6-phosphatase (G6Pase),
G6Pase-chloramphenicol acetyltransferase (CAT) fusion genes were transiently transfected
into either the liver-derived HepG2 or kidney-derived LLC-PK cell line. Co-transfection of an
expression vector encoding the catalytic subunit of cAMP-dependent protein kinase (PKA) …