[HTML][HTML] Tumor necrosis factor-α production is differently regulated in γδ and αβ human T lymphocytes
V Lafont, J Liautard, A Gross, JP Liautard… - Journal of Biological …, 2000 - ASBMB
Tumor necrosis factor-α (TNF-α) plays a crucial role in the early defense against pathogens.
This cytokine is produced by several cell types including T lymphocytes expressing the αβ
as well as the γδ T cell receptor (TcR). In human, the circulating γδ T cells, which mostly
express Vγ9Vδ2 TcR, have been strongly suggested to play an important protective role
against infectious agents. These activated cells early produce high amounts of TNF-α, which
induce a determinant beneficial effect against development of intracellular pathogens; …
This cytokine is produced by several cell types including T lymphocytes expressing the αβ
as well as the γδ T cell receptor (TcR). In human, the circulating γδ T cells, which mostly
express Vγ9Vδ2 TcR, have been strongly suggested to play an important protective role
against infectious agents. These activated cells early produce high amounts of TNF-α, which
induce a determinant beneficial effect against development of intracellular pathogens; …