γ/δ T-cell stimulation by pamidronate
V Kunzmann, E Bauer, M Wilhelm - New England Journal of …, 1999 - Mass Medical Soc
V Kunzmann, E Bauer, M Wilhelm
New England Journal of Medicine, 1999•Mass Medical SocTo the Editor: Bisphosphonates are widely used to inhibit osteoclastic bone resorption. As
analogues of pyrophosphate they share several structural homologies with recently
identified non-peptide γ/δ T-cell ligands, such as isopentenyl pyrophosphate, that activate
antigenic receptors of γ/δ T cells. 1 We recently found that aminobisphosphonates
(pamidronate, ibandronate, and alendronate) can stimulate the major subgroup of γ/δ T cells
in peripheral blood (Vγ9Vδ2+ T cells), whereas non-aminobisphosphonates (clodronate and …
analogues of pyrophosphate they share several structural homologies with recently
identified non-peptide γ/δ T-cell ligands, such as isopentenyl pyrophosphate, that activate
antigenic receptors of γ/δ T cells. 1 We recently found that aminobisphosphonates
(pamidronate, ibandronate, and alendronate) can stimulate the major subgroup of γ/δ T cells
in peripheral blood (Vγ9Vδ2+ T cells), whereas non-aminobisphosphonates (clodronate and …
To the Editor: Bisphosphonates are widely used to inhibit osteoclastic bone resorption. As analogues of pyrophosphate they share several structural homologies with recently identified non-peptide γ/δ T-cell ligands, such as isopentenyl pyrophosphate, that activate antigenic receptors of γ/δ T cells.1
We recently found that aminobisphosphonates (pamidronate, ibandronate, and alendronate) can stimulate the major subgroup of γ/δ T cells in peripheral blood (Vγ9Vδ2+ T cells), whereas non-aminobisphosphonates (clodronate and etidronate) are inactive. In our assays, pamidronate (concentration yielding half-maximal activity, 5 to 10 μM) induced the activation and selective expansion of γ/δ T cells in cultures of peripheral-blood mononuclear cells from . . .
The New England Journal Of Medicine