[HTML][HTML] Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC
M Baba, T Imai, M Nishimura, M Kakizaki… - Journal of Biological …, 1997 - ASBMB
Liver andactivation-regulated chemokine (LARC) is a recently identified CC chemokine that
is expressed mainly in the liver. LARC functions as a selective chemoattractant for
lymphocytes that express a class of receptors specifically binding to LARC with high affinity.
To identifiy the receptor for LARC, we examined LARC-induced calcium mobilization in cells
stably expressing five CC chemokine receptors (CCR1-CCR5) and five orphan seven-
transmembrane receptors. LARC specifically induced calcium flux in K562 cells as well as …
is expressed mainly in the liver. LARC functions as a selective chemoattractant for
lymphocytes that express a class of receptors specifically binding to LARC with high affinity.
To identifiy the receptor for LARC, we examined LARC-induced calcium mobilization in cells
stably expressing five CC chemokine receptors (CCR1-CCR5) and five orphan seven-
transmembrane receptors. LARC specifically induced calcium flux in K562 cells as well as …