[HTML][HTML] Chemoattractant receptors activate distinct pathways for chemotaxis and secretion: role of G-protein usage
B Haribabu, DV Zhelev, BC Pridgen… - Journal of Biological …, 1999 - ASBMB
Human leukocyte chemoattractant receptors activate chemotactic and cytotoxic pathways to
varying degrees and also activate different G-proteins depending on the receptor and the
cell-type. To determine the relationship between G-protein usage and the biological and
biochemical responses activated, receptors for the chemoattractants formyl peptides (FR),
platelet-activating factor (PAFR), and leukotriene B 4 (BLTR) were transfected into RBL-2H3
cells. Pertussis toxin (Ptx) served as a Gα i inhibitor. These receptors were chosen to …
varying degrees and also activate different G-proteins depending on the receptor and the
cell-type. To determine the relationship between G-protein usage and the biological and
biochemical responses activated, receptors for the chemoattractants formyl peptides (FR),
platelet-activating factor (PAFR), and leukotriene B 4 (BLTR) were transfected into RBL-2H3
cells. Pertussis toxin (Ptx) served as a Gα i inhibitor. These receptors were chosen to …